作者：

Jun Wang, Tingting Li, Jen-Shyang Ni, Heng Guo, Tianyi Kang, Zeshun Li, Menglei Zha,

Songbo Lu, Chen Zhang, Weizhi Qi, Lei Xi,* and Kai Li

引用瑞禧生物产品：

1,2-Distearoyl-snglycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]

(DSPE-PEG2000) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- [amino(polyethylene glycol)-2000] (DSPE-PEG2000-NH2)

引用瑞禧生物产品：DSPE-PEG2000-NH2 

摘要：

Precise and efficient delivery of nanomedicine to the target site has remained as a major roadblock in advanced cancer treatment. Here, a novel photoacoustic force (PAF)-guided nanotherapeutic system is reported based on a near-infrared (NIR)-absorbing semiconducting polymer (SP), showing significantly improved tumor accumulation and deep tissue penetration for enhanced phototherapeutic efficacy. The accumulation of nanoparticles in 4T1 tumor-bearing mice induced by the PAF strategy displays a fivefold enhancement in comparison with that of the traditional passive targeting pathway, in a significantly shortened time (45 min vs 24 h) with an enhanced penetration depth in tumors. Additionally, a tumor-bearing mouse model is rationally designed to unveil the mechanism, indicating that the nanoparticles enter solid tumors through enhanced transportation across blood vessel barriers via both inter-endothelial gaps and active trans-endothelial pathways. This process is specifically driven by PAF generated from the nanoparticles under NIR laser irradiation. The study thus demonstrates a new nanotherapeutic strategy with low dose, enhanced delivery efficiency in tumor, and boosted therapeutic efficacy, opening new doors for designing novel nanocarriers.

 引用瑞禧生物产品：DSPE-PEG2000-NH2

图1. SP NPs的合成与表征。a) SP的合成路线。b) SP NPs合成的示意图。c) 通过DLS和TEM测得的SP NPs的粒径分布及形貌。d) SP NPs在水性悬浮液中的归一化紫外-可见- NIR 吸收光谱与荧光发射光谱。e) SP NPs在水溶液中的光声光谱。

将纳米药物精准且高效地递送至靶部位，一直是先进癌症治疗中的主要障碍。本文报道了一种基于近红外（NIR）吸收半导体聚合物（SP）的新型光声力（PAF）引导纳米治疗系统，该系统在肿瘤蓄积量和深层组织穿透性方面均有显著提升，从而增强了光疗效果。在4T1荷瘤小鼠中，采用PAF策略诱导的纳米颗粒蓄积量较传统被动靶向途径提高了五倍，且所需时间显著缩短（45分钟 vs 24小时），同时在肿瘤中的穿透深度也显著增加。此外，本研究合理设计了荷瘤小鼠模型以揭示其作用机制，结果表明纳米颗粒通过内皮细胞间隙及主动跨内皮途径，增强穿越血管屏障的能力，终进入实体瘤。这一过程主要由纳米颗粒在 NIR 激光照射下产生的PAF驱动。本研究 thus 展示了一种新型纳米治疗策略，其特点包括低剂量、高肿瘤递送效率及增强的治疗效能，为设计新型纳米载体开辟了新途径。